The purpose of this talk is to introduce the breadth of multidisciplinary development that enabled marvelous advances in the field of biomedical ultrasound. Over the past century this field has evolved into one of the most profoundly interdisciplinary domains in modern science and medicine. That was achieved by a close collaboration between the scholars working on the intersection of biology, chemistry, physics, engineering, and clinical practice. The talk will attempt to demonstrate how interdisciplinary background of ultrasound researchers led to the unprecedented rise of ultrasound from a primarily diagnostic modality into a versatile platform for precision imaging, targeted therapy, and neuromodulation. Selected examples will highlight the transformation of diagnostic ultrasound into a plethora of therapeutic treatments. High-frequency (15 MHz+) ultrasound, elastography, and contrast-enhanced techniques now enable real-time visualization of tissue architecture, perfusion, and mechanobiological changes with exceptional submillimeter resolution. In parallel, therapeutic ultrasound has entered a new era defined by noninvasive, cell-specific interventions. Low-intensity (<1W/cm2) focused ultrasound (LIFU) and ultrasound-mediated drug delivery are emerging as transformative tools in neuroengineering and the treatment of the neuropsychiatric disorders. By modulating neural activity without surgery, ultrasound offers promising avenues for managing Parkinson’s disease, Alzheimer’s pathology, chronic pain, and addiction. Presentation of the comprehensive chart of applications will deliver the audience coherent and lucid view of the opportunities to work with the ultrasound technology in academic, industrial and clinical environment.
